Tag Archives: Modelling

Hepatocyte specific model

Starting with the thermodynamically curated human genome-scale Recon 3D^30,31, we reconstructed a hepatocyte metabolic model by taking into account the physiology of hepatocytes and the genes expressed in liver cells. Towards this end, we defined the physiology of hepatocytes by integrating in the human Recon3D model publicly available fluxomics data for 92 boundary reactions²⁸ and metabolomics data for 213 metabolites²⁹ from previous hepatocyte model reconstructions. Additionally, we set the growth rate of the hepatocyte to a maximum of 0.014 h⁻¹ corresponding to a doubling time of 49.5 h⁴⁹ and the ATP maintenance rate to at least 1.07 mmol/gDW/h⁵⁰. The Human Protein Atlas (www.proteinatlas.org)²⁷ was used to identify 1853 metabolic genes present in…

Tell us about IriusRisk

 
IriusRisk is the industry’s leading threat modeling and secure design solution that allows engineering teams to design secure software from the start. Every sector of the global economy is being transformed by software, yet software vulnerabilities are frequently exposed by cyber attacks. More than half of these vulnerabilities are flaws in the design of the system. IriusRisk helps non-security experts identify these software security design flaws before they write a line of code.

IriusRisk works with clients that include four of the top 10 Globally Systemically Important Banks (G-SIBs) to automate the process of threat modeling and enable organisations to design secure software, at scale.
 
 

 
 

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